Two novel SNPs rs1736952 and rs17354984 are highly associated with uveitis in ankylosing spondylitis
學年 113
學期 2
出版（發表）日期 2025-03-01
作品名稱 Two novel SNPs rs1736952 and rs17354984 are highly associated with uveitis in ankylosing spondylitis
作品名稱（其他語言）
著者 Ssu-Chenga Huang; De-KuangHwang; Wei-Chieh Fang; Ai-Ru Hsieh; Mei-Line Shih; Zi-Qing Zhuang; Chong-En Gao, Tai-Chi Lin; Shih-Jen Chen; Chih-Chien Hsu
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出版者
著錄名稱、卷期、頁數 Journal of the Chinese Medical Association 88(3), p 211-221
摘要 Background: Noninfectious anterior uveitis shares genetic factors, including HLA-B27, with ankylosing spondylitis (AS). The aim of this study was to identify significant single nucleotide polymorphisms (SNPs) associated with noninfectious anterior uveitis in AS patients, which may help predict help predict the risk of developing this condition and provide deeper insights into its genetic basis. Methods: A genome-wide association study (GWAS) was conducted using the genomic data of 468 AS patients, including 90 with noninfectious anterior uveitis and 378 without it, from the Taiwan Precision Medicine Initiative. This study identified relevant genes using SnpXplorer and developed a polygenic risk score (PRS) model to identify AS patients with an increased risk of noninfectious anterior uveitis. Biological pathways were analyzed via Enrichr-KG and various databases. Results: GWAS revealed two novel SNPs, rs1736952 and rs17354984, with p values <5 × 10−8, and 74 SNPs with p values <1 × 10−4. The associated genes were involved mainly in antigen presentation, interferon signaling, immune regulation pathways, ciliary movement, and neurodegeneration. An optimal PRS model was constructed using 19 SNPs, achieving an area under the curve (AUC) of 0.907. Conclusion: Our results revealed that two novel and significant SNP loci, rs1736952 and rs17354984, are strongly associated with noninfectious anterior uveitis in patients with AS. However, their roles in uveitis and other immune disorders warrant further investigation.
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語言 zh_TW
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期刊性質 國外
收錄於 SCI
產學合作
通訊作者
審稿制度 否
國別 TWN
公開徵稿
出版型式 ,電子版
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機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/127346 )