The art of biodegradable polymer design for the treatments against osteomyelitis
學年 113
學期 1
出版（發表）日期 2025-01-15
作品名稱 The art of biodegradable polymer design for the treatments against osteomyelitis
作品名稱（其他語言）
著者 Dhayanithi Senthilkumar; Trong-Ming Don; Yu-Jie Liao; Chih-Yu Kuo
單位
出版者
著錄名稱、卷期、頁數 International Journal of Biological Macromolecules 285 (2025) 138347
摘要 Osteomyelitis arises from the incomplete treatment of the external wounds in the healing process, while bacterial infections persist within the bone marrow, leading to abscess formation. Osteomyelitis treatments generally involve three main aspects: rapid bactericidal action, sustained bacteriostasis, and induction of bone regeneration. However, current treatment methods, which often combine surgical debridement with long-term high-dose intravenous antibiotic administration or poly(methyl methacrylate) (PMMA) beads antibiotic therapy, suffer from significant drawbacks and limitations. In an era focused on environmental protection and sustainability, there is potential for biodegradable polymers to replace non-degradable plastic materials to reduce environmental pollution and achieve sustainable development in resources, society, and the economy. With this in mind, this review aims to explore the concept and design of applying various natural biodegradable polymers like gelatin, chitosan, cellulose, etc., and synthetic biodegradable polymers like polylactic acid, poly(lactic-co-glycolic) acid, polycaprolactone, etc. for osteomyelitis treatment, including (1) replacing PMMA with biodegradable polymer beads, (2) biodegradable polymer coatings on medical implants, (3) injectable biodegradable polymer hydrogels, and (4) biodegradable polymers as scaffolds for osteogenic cell growth. This article contributes to understanding and advancing biodegradable polymer applications in biomedicine through a comprehensive review and discussion of these four aspects.
關鍵字
語言 en
ISSN
期刊性質 國外
收錄於 SCI
產學合作
通訊作者 Trong-Ming Don and Chih-Yu Kuo
審稿制度 是
國別 NLD
公開徵稿
出版型式 ,電子版,紙本
相關連結

機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/126601 )