| Synthesis of Flavonols and Assessment of Their Biological Activity as Anticancer Agents | |
|---|---|
| 學年 | 112 |
| 學期 | 2 |
| 出版（發表）日期 | 2024-04-28 |
| 作品名稱 | Synthesis of Flavonols and Assessment of Their Biological Activity as Anticancer Agents |
| 作品名稱（其他語言） | |
| 著者 | Hsu, Pei-hsuan; Cheng,Yang-je; Shih, Tzenge-lien |
| 單位 | |
| 出版者 | |
| 著錄名稱、卷期、頁數 | Molecules 29(9), 2041 |
| 摘要 | A series of flavanols were synthesized to assess their biological activity against human non-small cell lung cancer cells (A549). Among the sixteen synthesized compounds, it was observed that compounds 6k (3.14 ± 0.29 µM) and 6l (0.46 ± 0.02 µM) exhibited higher potency compared to 5-fluorouracil (5-Fu, 4.98 ± 0.41 µM), a clinical anticancer drug which was used as a positive control. Moreover, compound 6l (4’-bromoflavonol) markedly induced apoptosis of A549 cells through the mitochondrial- and caspase-3-dependent pathways. Consequently, compound 6l might be developed as a candidate for treating or preventing lung cancer. |
| 關鍵字 | anticancer agent;human non-small cell lung cancer cell;flavonol |
| 語言 | en_US |
| ISSN | 1420-3049 |
| 期刊性質 | 國外 |
| 收錄於 | SCI Scopus |
| 產學合作 | |
| 通訊作者 | |
| 審稿制度 | 否 |
| 國別 | SWE |
| 公開徵稿 | |
| 出版型式 | ,電子版 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/125701 ) |
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