| Synthesis and Evaluation of 6‐Amino‐2‐styrylchromones as Anticancer Agents | |
|---|---|
| 學年 | 111 |
| 學期 | 2 |
| 出版（發表）日期 | 2023-05-08 |
| 作品名稱 | Synthesis and Evaluation of 6‐Amino‐2‐styrylchromones as Anticancer Agents |
| 作品名稱（其他語言） | |
| 著者 | Ya‐Chen Chen; Yi‐Cheng Chu; Cai‐Wei Li; Jih‐Jung Chen; Tzenge‐Lien Shih |
| 單位 | |
| 出版者 | |
| 著錄名稱、卷期、頁數 | ChemistrySelect 8, e202300685 |
| 摘要 | 2-Styrylchromones, a C-2 styrene derivative of chromones, possess a broad spectrum of biological activity. However, 2-styrylchromones are scarce in nature but not to mention the amino-substituted styrylchromones. We have synthesized fourteen 6-amino-2-styrylchromones and evaluated their anti-cancer activity on human caucasian colon adenocarcinoma cells (HT-29). 6-Amino-2-styrylchromones and related derivatives have never been revealed their pharmacology profiles. Among the novel fourteen compounds, we reported that compound 9 h exhibited its potential with the comparable activity with 5-flurouracil (5-FU) as a referenced drug. |
| 關鍵字 | |
| 語言 | en |
| ISSN | 2365-6549 |
| 期刊性質 | 國外 |
| 收錄於 | SCI |
| 產學合作 | |
| 通訊作者 | |
| 審稿制度 | 是 |
| 國別 | GBR |
| 公開徵稿 | |
| 出版型式 | ,電子版 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/124080 ) |
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