Quality of life changes in patients undergoing treatment for hepatocellular carcinoma
學年 103
學期 2
出版（發表）日期 2015-05-06
作品名稱 Quality of life changes in patients undergoing treatment for hepatocellular carcinoma
作品名稱（其他語言）
著者 Wei-Chu Chie; Fang Yu; Mengqian Li; Lorena Baccaglini; Jane M Blazeby; Chin-Fu Hsiao; Herng-Chia Chiu; Ronnie T Poon; Naoko Mikoshiba; Gillian Al-Kadhimi; Nigel Heaton; Jozer Calara; Peter Collins; Katharine Caddick; Anna Costantini; Valerie Vilgrain; Chieh Chiang
單位
出版者
著錄名稱、卷期、頁數 Quality of Life Research 24(10), 2499-2506
摘要 Purpose Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide. One of the primary treatment goals for incurable advanced cases is to prolong quality of life (QoL). Thus, to determine which HCC therapies may be linked to a more favorable QoL, we assessed the association between QoL changes and different treatments in HCC patients. Methods We analyzed a non-randomized multicenter longitudinal study, which included 171 patients treated with surgery (n = 53), ablation (n = 53) or embolization (n = 65) from seven centers: four Asian and three European sites. All participants completed the EORTC QLQ-C30 and QLQ-HCC18 questionnaires before and after treatment. Propensity scores were calculated and used in addition to race for adjustment in the logistic regression model to account for the confounding effects of patient characteristics including age, gender, race, employment, living with family, at least one comorbid condition, years since diagnosis, prior treatment history, BCLC stage, Child–Pugh grade, cirrhosis, bilirubin levels and QoL score before treatment. Results After adjustment for confounders, patients tended to have higher odds of QoL deterioration when treated with ablation versus embolization (dyspnea: p = 0.019; appetite loss: p = 0.018; body image: p = 0.035) or ablation versus surgery (dyspnea: p = 0.099; appetite loss: p = 0.100; body image: p = 0.038). Conclusions There were significant differences in QoL deterioration across different treatment groups. This information may assist patients and providers when selecting patient-centered treatment approaches for HCC.
關鍵字 Quality of life;Asian;Treatment;Hepatocellular;Carcinoma
語言 en_US
ISSN 0962-9343
期刊性質 國外
收錄於 SCI
產學合作
通訊作者
審稿制度 否
國別 USA
公開徵稿
出版型式 ,電子版
相關連結

機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/122692 )