A novel naphthalimide derivative reduces platelet activation and thrombus formation via suppressing GPVI
學年 110
學期 1
出版（發表）日期 2021-08-27
作品名稱 A novel naphthalimide derivative reduces platelet activation and thrombus formation via suppressing GPVI
作品名稱（其他語言）
著者 Tzenge-Lien Shih; Kuan-Hung Lin; Ray-Jade Chen; Ting-Yu Chen; Wei-Ting Kao; Jen-Wei Liu; Hsueh-Hsiao Wang; Hsien-Yu Peng; Yu-Yo Sun; Wan-Jung Lu
單位
出版者
著錄名稱、卷期、頁數 Journal of Cellular and Molecular Medicine 25(19), p.9434-9446
摘要 Naphthalimide derivatives have multiple biological activities, including antitumour and anti-inflammatory activities. We previously synthesized several naphthalimide derivatives; of them, compound 5 was found to exert the strongest inhibitory effect on human DNA topoisomerase II activity. However, the effects of naphthalimide derivatives on platelet activation have not yet been investigated. Therefore, the mechanism underlying the antiplatelet activity of compound 5 was determined in this study. The data revealed that compound 5 (5–10 μM) inhibited collagen- and convulxin- but not thrombin- or U46619-mediated platelet aggregation, suggesting that compound 5 is more sensitive to the inhibition of glycoprotein VI (GPVI) signalling. Indeed, compound 5 could inhibit the phosphorylation of signalling molecules downstream of GPVI, followed by the inhibition of calcium mobilization, granule release and GPIIb/IIIa activation. Moreover, compound 5 prevented pulmonary embolism and prolonged the occlusion time, but tended to prolong the bleeding time, indicating that it can prevent thrombus formation but may increase bleeding risk. This study is the first to demonstrate that the naphthalimide derivative compound 5 exerts antiplatelet and antithrombotic effects. Future studies should modify compound 5 to synthesize more potent and efficient antiplatelet agents while minimizing bleeding risk, which may offer a therapeutic potential for cardiovascular diseases.
關鍵字
語言 en_US
ISSN 1582-4934
期刊性質 國外
收錄於 SCI
產學合作
通訊作者
審稿制度 是
國別 GBR
公開徵稿
出版型式 ,電子版
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機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/121477 )