Hypoperfusion of the infrapatellar fat pad and its relationship to MRI T2* relaxation time changes in a 5/6 nephrectomy model
學年 109
學期 2
出版（發表）日期 2021-05-11
作品名稱 Hypoperfusion of the infrapatellar fat pad and its relationship to MRI T2* relaxation time changes in a 5/6 nephrectomy model
作品名稱（其他語言）
著者 Guo-Shu Huang; Yi-Jen Peng; Yu-Juei Hsu; Herng-Sheng Lee; Yue-Cune Chang; Shih-Wei Chiang; Yi-Chih Hsu; Ying-Chun Liu; Ming-Huang Lin; Chao-Ying Wang
單位
出版者
著錄名稱、卷期、頁數 Scientific Reports 11(1), 9924
摘要 The purpose of present study was to longitudinally investigate the alterations in infrapatellar fat pad (IPFP) vascularity in 5/6 nephrectomized rats by using dynamic contrast enhanced (DCE) MRI and IPFP degeneration by using MRI T2* relaxation time. Twelve male Sprague-Dawley rats were assigned to a control group and a 5/6 nephrectomy CKD group. The right knees of all rats were longitudinally scanned by 4.7 T MRI, and serial changes in the IPFP were assessed at 0, 8, 16, 30, and 44 weeks by DCE-MRI (parameters A, kel and kep) and MRI T2* mapping. After MRI measurements, knee specimens were obtained and evaluated histologically. The CKD group had IPFPs with lower blood volume A and lower permeability kep values from 16 weeks (p < 0.05), lower venous washout kel value from 30 weeks (p < 0.001), and significantly higher T2* values reflecting adipocyte degeneration beginning at 16 weeks (p < 0.05). The histopathological results confirmed the MRI findings. Hypoperfusion and adipocytes degeneration related to CKD were demonstrated in a rodent 5/6 nephrectomy model. DCE parameters and MRI T2* can serve as imaging biomarkers of fat pad degeneration during CKD progression.
關鍵字 Chronic kidney disease;Magnetic resonance imaging;Musculoskeletal system
語言 en_US
ISSN 2045-2322
期刊性質 國外
收錄於 SCI Scopus
產學合作
通訊作者 Chao-Ying Wang
審稿制度 是
國別 GBR
公開徵稿
出版型式 ,電子版
相關連結

機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/120826 )