Assessment of the efficacy of intra-articular platelet rich plasma treatment in an ACLT experimental model by dynamic contrast enhancement MRI of knee subchondral bone marrow and MRI T2∗ measurement of articular cartilage
學年 109
學期 2
出版（發表）日期 2021-02-10
作品名稱 Assessment of the efficacy of intra-articular platelet rich plasma treatment in an ACLT experimental model by dynamic contrast enhancement MRI of knee subchondral bone marrow and MRI T2∗ measurement of articular cartilage
作品名稱（其他語言）
著者 Guo-Shu Huang; Yi-Jen Peng; Dennis W. Hwang; Herng-Sheng Lee; Yue-Cune Chang; Shih-Wei Chiang; Yi-Chih Hsu; Ying-Chun Liu; Ming-Huang Lin; Chao-Ying Wang
單位
出版者
著錄名稱、卷期、頁數 Osteoarthritis and Cartilage 29(5), p.718-727
摘要 Objective: The vascularization of subchondral bone plays a significant role in the progression of knee osteoarthritis (OA). Treatment with platelet-rich plasma (PRP) has positive effects on cartilage lesions. However, PRP's efficacy for subchondral bone marrow lesions and the relationship of these lesions to cartilage are still undiscovered. Therefore, our aims were first to longitudinally investigate the change in subchondral flow by dynamic contrast enhanced MRI and degeneration of cartilage by MRI T2* in an anterior cruciate transection rodent (ACLT) model, and second to examine changes in parameters after intra-articular PRP injection. Design: A 32-week investigation in 18 rats allocated to sham-control, ACLT with normal saline injection (ACLT þ NS), and ACLT with PRP injection groups ended with histological evaluation. Another rat was used as a donor of allogenic PRP. Results: Compared to the sham-control group, the ACLT þ NS group had higher subchondral blood volume A (0.051, 95% confidence interval: 0.009, 0.092) and lower venous washout kel (0.030: 0.055, 0.005) from week 4; lower permeability kep from week 18 (0.954: 1.339, 0.569); higher cartilage T2* values (1.803: 1.504, 2.102) reflecting collagen loss beginning at week 10. For the PRP treatment group, subchondral bone marrow A and cartilage T2* decreased from week 10. Histological results confirmed and were correlated with the MRI findings. Conclusion: Subchondral hyper-perfusion plays a vital role in the pathogenesis of OA and was associated with cartilage degeneration. The efficacy of PRP can be observed from reduced perfusion and MRI T2* values
關鍵字 Subchondral bone vascularization;Platelet rich plasma;Osteoarthritis;Anterior cruciate ligament transection;Dynamic contrast enhanced MRI;MRI T2*
語言 en_US
ISSN 1522-9653
期刊性質 國外
收錄於 SCI Scopus
產學合作
通訊作者 Chao-Ying Wang
審稿制度 是
國別 USA
公開徵稿
出版型式 ,電子版
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