Efficient Photodynamic Killing of Gram-Positive Bacteria by Synthetic Curcuminoids
學年 109
學期 1
出版（發表）日期 2020-12-01
作品名稱 Efficient Photodynamic Killing of Gram-Positive Bacteria by Synthetic Curcuminoids
作品名稱（其他語言）
著者 Sung-Jen Hung; Yi-An Hong; Kai-Yu Lin; Yi-Wen Hua; Chia-Jou Kuo; Anren Hu; Tzenge-Lien Shih; Hao-Ping Chen
單位
出版者
著錄名稱、卷期、頁數 International Journal of Molecular Sciences 21(23), 9024
摘要 In our previous study, we have demonstrated that curcumin can efficiently kill the anaerobic bacterium Propionibacterium acnes by irradiation with low-dose blue light. The curcuminoids present in natural plant turmeric mainly include curcumin, demethoxycurcumin, and bisdemethoxycurcumin. However, only curcumin is commercially available. Eighteen different curcumin analogs, including demethoxycurcumin and bisdemethoxycurcumin, were synthesized in this study. Their antibacterial activity against Gram-positive aerobic bacteria Staphylococcus aureus and Staphylococcus epidermidis was investigated using the photodynamic inactivation method. Among the three compounds in turmeric, curcumin activity is the weakest, and bisdemethoxycurcumin possesses the strongest activity. However, two synthetic compounds, (1E,6E)-1,7-bis(4-bromophenyl)hepta-1,6-diene-3,5-dione and (1E,6E)-1,7-bis(3-bromophenyl)hepta -1,6-diene-3,5-dione, possess the best antibacterial activity among all compounds examined in this study. Their chemical stability is also better than that of bisdemethoxycurcumin, and thus has potential for future clinical applications.
關鍵字 bisdemethoxycurcumin;curcumin;curcuminoid;demethoxycurcumin;photodynamic inactivation;Staphylococcus aureus;Staphylococcus epidermis
語言 en
ISSN 1422-0067
期刊性質 國外
收錄於 SCI
產學合作
通訊作者 Tzenge-Lien SHih
審稿制度 是
國別 CHE
公開徵稿
出版型式 ,電子版
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