Autism Associated With Anti-NMDAR Encephalitis: Glutamate-Related Therapy
學年 107
學期 2
出版（發表）日期 2019-06-21
作品名稱 Autism Associated With Anti-NMDAR Encephalitis: Glutamate-Related Therapy
作品名稱（其他語言）
著者 Ruu-Fen Tzang; Chuan-Hsin Chang; Yue-Cune Chang; Hsien-Yuan Lane
單位
出版者
著錄名稱、卷期、頁數 Frontiers in Psychiatry 10, p.440
摘要 The purpose of this review is to correlate autism with autoimmune dysfunction in the absence of an explanation for the etiology of autism spectrum disorder. The anti-N-methyl-Daspartate receptor (anti-NMDAR) autoantibody is a typical synaptic protein that can bind to synaptic NMDA glutamate receptors, leading to dysfunctional glutamate neurotransmission in the brain that manifests as psychiatric symptoms (psychosis, hallucinations, and personality changes). Detection of autoantibodies, cytokines, decreased lymphocytes, serum immunoglobulin level imbalance, T-cell mediated immune profile, maternal infection history, and children’s infection history can all be vital biological markers of autoimmune autism. Diagnosing autoimmune encephalitis sooner can increase the effectiveness of curative treatments—such as immune therapy or immune modulatory therapy—that may prevent the long-term consequence of being misdiagnosed with autism spectrum disorder. Glutamate therapy primarily normalizes glutamate neurotransmission and can be a new add-on intervention alongside antipsychotics for treating autoimmune autism.
關鍵字 autoimmune autism;glutamate-related therapy;anti-N-methyl-D-aspartate receptor encephalitis;immune therapy;dysfunctional glutamate neurotransmission
語言 en_US
ISSN
期刊性質 國外
收錄於 SCI
產學合作
通訊作者 Hsien-Yuan Lane
審稿制度 是
國別 USA
公開徵稿
出版型式 ,電子版
相關連結

機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/116939 )