Gamma knife radiosurgery for the treatment of cavernous sinus meningiomas: post-treatment long-term clinical outcomes, complications, and volume changes
學年 107
學期 2
出版（發表）日期 2019-04-24
作品名稱 Gamma knife radiosurgery for the treatment of cavernous sinus meningiomas: post-treatment long-term clinical outcomes, complications, and volume changes
作品名稱（其他語言）
著者 Yi‑Chieh Hung; Cheng‑Chia Lee; Wan‑Yuo Guo; Cheng‑Ying Shiau; Yue‑Cune Chang; David Hung‑Chi Pan; Jason P. Sheehan; Wen‑Yuh Chung
單位
出版者
著錄名稱、卷期、頁數 Journal of Neuro-oncology 141(2), p.261-270
摘要 Purpose To evaluate the outcomes of patients who underwent Gamma Knife radiosurgery (GKRS) for the treatment of cavernous sinus (CS) meningiomas. Methods We retrospectively reviewed the clinical and radiological outcomes of 95 patients with CS meningiomas at Taipei Veterans General Hospital between 1993 and 2011. The study cohort comprised 27 men and 68 women with a median age of 50 years (range 29–79 years). The median pre-GKRS tumor volume was 6.6 ml (range 0.9–35.7 ml). The median margin dose was 12 Gy (range 11–21 Gy). The clinical factors related to favorable outcomes were assessed. Results The median follow-up period was 59 (range 12–209) months. At the final follow-up, the tumor volume regressed in 70 patients (74%) and progressed in eight (8%). Kaplan–Meier analysis revealed that the progression-free survival rates at 5 and 10 years were 92.7% and 81.2%, respectively. Three patients (3.2%) experienced exacerbated cranial nerve dysfunction following radiosurgery. Confined tumors were found to be an independent prognostic factor for tumor control and shorter times to regression in the multivariable analyses. No risk factor for tumor progression was identified in either the univariate or multivariate analyses. Conclusions GKRS provides good long-term tumor control and is associated with low cranial nerve–related morbidity development rates in patients with small- to medium-sized CS meningiomas. Confined tumor could be an independent prognostic factor for tumor control and shorter times to regression in multivariate analysis. Life-long follow-up is mandatory in such settings, even for outpatients with shrunken or stabilized tumors.
關鍵字 Cavernous sinus;Meningioma;Prognostic factor;Radiosurgery
語言 en_US
ISSN
期刊性質 國外
收錄於 SCI
產學合作
通訊作者 Wen‑Yuh Chung
審稿制度 否
國別 USA
公開徵稿
出版型式 ,電子版
相關連結

機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/116937 )