Low Diastolic Blood Pressure and High Blood Pressure Variability are Risk Factors for Cognitive Decline in Elderly Adults: A Case-Control Study
學年 107
學期 1
出版（發表）日期 2018-12-29
作品名稱 Low Diastolic Blood Pressure and High Blood Pressure Variability are Risk Factors for Cognitive Decline in Elderly Adults: A Case-Control Study
作品名稱（其他語言）
著者 Chia-Chi Chen; Jia-Fu Lee; Yu-Lin Ko; Chun-Te Lee; Yue-Cune Chang
單位
出版者
著錄名稱、卷期、頁數 Neuropsychiatry (London) 8(6), p.1986-1992
摘要 Background This study investigated the association between visit-to-visit blood pressure (BP) variability and cognitive decline in elderly adults over a 4-month period. Methods All 94 elderly volunteers were recruited from a community center. Mini-Mental Status Examination (MMSE) and Clinical Dementia Rating (CDR) questionnaires were administered during the initial assessment and at 4 months after the service. The BP at each visit and the visit-to-visit BP variability were measured for 4 consecutive months. Results The middle-stage/moderate cognitive impairment (MMSE scores ≤ 21) group exhibited significantly lower minimum diastolic BP and higher diastolic coefficient of variation values than did the mild/no cognitive impairment (MMSE scores >21) group did. After adjustment for the effects of age, the minimum diastolic BP was significantly and positively associated with the MMSE scores (P=0.033). To further evaluate the effects of low diastolic BP (LDBP) on cognitive function, we compared the initial and 4-month MMSE scores between the LDBP group (minimum diastolic BP ≤ 50 mmHg) and the control group (minimum diastolic BP>50 mmHg). We divided the volunteers into the following 4 groups: (1) hypertension history with LDBP (HT-c-LDBP), (2) hypertension history without LDBP (HT-s-LDBP), (3) no hypertension history without LDBP (nHT-s-LDBP), and (4) no hypertension history with LDBP (nHT-c-LDBP). The cognitive function differed significantly among the four groups (MMSE scores: HT-c-LDBP=21.62 ± 2.87; HT-s-LDBP=25.20 ± 2.78; nHT-s-LDBP=26.12 ± 3.65; and nHT-c-LDBP=23.27 ± 3.16). Compared to the nHT-s-LDBP group, the data showed that the HT-c-LDBP group exhibited significantly worse cognitive function, followed by the nHT-c-LDBP group. Conclusions LDBP and high diastolic BP variability are risk factors for cognitive function decline in elderly adults.
關鍵字 Diastolic blood pressure;Blood pressure variability;Cognitive decline;Elderly adults
語言 en_US
ISSN 1758-2008
期刊性質 國外
收錄於
產學合作
通訊作者
審稿制度 是
國別 USA
公開徵稿
出版型式 ,電子版,紙本
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機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/115984 )