Isolation and identification of potent antidiabetic compounds from Antrodia cinnamomea - An edible Taiwanese mushroom
學年 107
學期 1
出版（發表）日期 2018-11-02
作品名稱 Isolation and identification of potent antidiabetic compounds from Antrodia cinnamomea - An edible Taiwanese mushroom
作品名稱（其他語言）
著者 Hung Tse Huang; San-Lang Wang; Van Bon Nguyen; Yao-Haur Kuo
單位
出版者
著錄名稱、卷期、頁數 Molecules 23(11), 2864
摘要 Antrodia cinnamomea (AC), an edible Taiwanese mushroom, has been recognized as a valuable natural resource with vast biological and medicinal benefits. Recently, the hypoglycemic and anti-diabetic effects of AC were mentioned in several studies. However, no studies have investigated α-glucosidase inhibitors from AC fruiting bodies (ACFB) as they relate to type 2 diabetes (T2D) treatment. The purpose of this study was to gain evidence of potent α-glucosidase inhibitory effects, as well as isolate, identify and characterize the active compounds of ACFB. The MeOH extract of ACFB demonstrated potent α-glucosidase inhibitory activity, and possessed high pH stability (pH 2–11) and thermostable properties at 40–50 ◦C. Further purification led to the isolation of eight constituents from ACFB, identified as: 25S-antcin K (1), 25R-antcin K (2), dehydrosulphurenic acid (3), 25S-antcin I (4), 25S-antcin B (5), 25R-antcin B (6), dehydroeburicoic acid (7) and eburicoic acid (8). Notably, the ACFB extract and its identified compounds, except 1, 4, and 6 demonstrated a greater effect (EC50 = 0.025–0.21 mg/mL) than acarbose (EC50 = 0.278 mg/mL). As such, these active compounds were determined to be new potent mushroom α-glucosidase inhibitors. These active compounds were also identified on the HPLC fingerprints of ACFB.
關鍵字 Antrodia cinnamomea; antidiabetic; edible mushroom; α-glucosidase inhibitor; antcin K; dehydrosulphurenic acid; dehydroeburicoic acid; eburicoic acid
語言 zh_TW
ISSN 1420-3049
期刊性質 國外
收錄於 SCI
產學合作
通訊作者 San-Lang Wang
審稿制度 是
國別 TWN
公開徵稿
出版型式 ,電子版
相關連結

機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/115558 )