New novel α–glucosidase inhibitors produced by microbial conversion
學年 106
學期 2
出版（發表）日期 2018-02-01
作品名稱 New novel α–glucosidase inhibitors produced by microbial conversion
作品名稱（其他語言）
著者 Nguyen Van Bon, Wang San-Lang
單位
出版者
著錄名稱、卷期、頁數 Process Biochemistry 65, p.228-232
摘要 Fermented Nutrient Broth (FNB) was found to be a potential source of antidiabetic drugs in the previous report. Thus, FNB was employed to isolate the active compounds in this study. Novel 5 α-glucosidase inhibitors (aGIs) were isolated from FNB and identified as: (1) Adenine, (2) 3-hydroxyproline, (3) Creatinine, (4) Nicotinic acid, and (5) Niacinamide. Notably, these inhibitors were found as new microbial aGIs, non-sugar-based moiety aGIs. Of these inhibitors, compounds 2 and 4 showed activity against rat α-glucosidase equal to, or stronger than, that of acarbose, with the IC50 values of 100, 67, and 115 μg/mL, respectively. These results contributed to enriching the current poor novel microbial aGIs, and also confirmed that FNB shows promising utilization for diabetes and obesity treatments or health foods due to their containing efficient mammalian aGIs.
關鍵字 α–glucosidase inhibitor;Paenibacillus sp.;Diabetes;Microbial conversion
語言 en
ISSN 1359-5113
期刊性質 國外
收錄於 SCI EI
產學合作
通訊作者 WANG San-Lang
審稿制度 是
國別 USA
公開徵稿
出版型式 ,電子版
相關連結

機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/112696 )