Isolation and identification of novel α-amylase inhibitors from Euonymus laxiflorus Champ
學年 106
學期 2
出版（發表）日期 2018-02-01
作品名稱 Isolation and identification of novel α-amylase inhibitors from Euonymus laxiflorus Champ
作品名稱（其他語言）
著者 Nguyen VB; Wang SL; Nguyen AD; Vo TPK; Zhang LJ; Nguyen QV; Kuo YH
單位
出版者
著錄名稱、卷期、頁數 Research on Chemical Intermediates 44(2), p.1411-1424
摘要 Euonymus laxiflorus Champ. (ELC) has been reported to possess potential antidiabetic activity. The aim of this study is to isolate and identify the active compounds in ELC extract. Application of effective techniques including Diaoin, octadecylsilane opened columns, dialysis, and preparative high-performance liquid chromatography (HPLC) coupled with a biologically guided assay resulted in isolation of 11 novel active compounds. Five compounds were identified as new α-amylase inhibitors (αAIs), viz. walterolactone A/B β-D-pyranoglucoside (1), schweinfurthinol 9-O-β-D-pyranoglucoside (10), 1-O-(3-methyl)-butenoyl-myoinositol (11), leonuriside (13), and (3,5-dimethoxy-4-hydroxyphenol) -1-O-β-D-(6′-O-galloyl)-glucopyranoside (21). Among these inhibitors, three compounds (1, 10, 11) were characterized as new. Another six known compounds (2, 9, 16, 17, 18, 19) were determined as phenolic. Notably, six compounds (1, 2, 9, 13, 16, 17) demonstrated significant activity, comparable to or higher than that of acarbose, a commercial antidiabetic drug, based on t test ranking. The relationship between the chemical structures and bioactivity of the inhibitors is also reported.
關鍵字 α-amylase inhibitor;Euonymus laxiflorus Champ.;Medicinal plants;Diabetes;Obesity;Bioactive compounds
語言 en
ISSN 0922-6168
期刊性質 國內
收錄於 SCI
產學合作
通訊作者 WANG San-Lang
審稿制度 是
國別 USA
公開徵稿
出版型式 ,電子版
相關連結

機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/112608 )