Reclamation of marine chitinous materials for the production of α-glucosdase inhibitors via microbial conversion
學年 106
學期 1
出版（發表）日期 2017-11-07
作品名稱 Reclamation of marine chitinous materials for the production of α-glucosdase inhibitors via microbial conversion
作品名稱（其他語言）
著者 Van Bon Nguyen; San-Lang Wang
單位
出版者
著錄名稱、卷期、頁數 Marine Drugs 15(11), p.350(11 pages)
摘要 Six kinds of chitinous materials have been used as sole carbon/nitrogen (C/N) sources for producing α-glucosidase inhibitors (aGI) by Paenibacillus sp. TKU042. The aGI productivity was found to be highest in the culture supernatants using demineralized crab shell powder (deCSP) and demineralized shrimp shell powder (deSSP) as the C/N source. The half maximal inhibitory concentration (IC50) and maximum aGI activity of fermented deCSP (38 µg/mL, 98%), deSSP (108 µg/mL, 89%), squid pen powder (SPP) (422 µg/mL, 98%), and shrimp head powder (SHP) (455 µg/mL, 92%) were compared with those of fermented nutrient broth (FNB) (81 µg/mL, 93%) and acarbose (1095 µg/mL, 74%), a commercial antidiabetic drug. The result of the protein/chitin ratio on aGI production showed that the optimal ratio was 0.2/1. Fermented deCSP showed lower IC50 and higher maximum inhibitory activity than those of acarbose against rat intestinal α-glucosidase.
關鍵字 chitin;crab shells;α-glucosidase inhibitor;Paenibacillus;diabetes
語言 en
ISSN 1660-3397
期刊性質 國外
收錄於 SCI
產學合作
通訊作者 San-Lang Wang
審稿制度 否
國別 SWE
公開徵稿
出版型式 ,電子版
相關連結

機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/112049 )

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