Synthesis of 3-Substituted Indole by AlCl3 Promoted Reaction of α,β-Unsaturated Ketone with Indole
學年 102
學期 2
出版（發表）日期 2014-03-27
作品名稱 Synthesis of 3-Substituted Indole by AlCl3 Promoted Reaction of α,β-Unsaturated Ketone with Indole
作品名稱（其他語言）
著者 Lee, Shih-yuan
單位
出版者
著錄名稱、卷期、頁數 Research on Chemical Intermediates 40,　p.2277-2285
摘要 A one-pot Lewis acid-promoted reaction condition of β,γ-unsaturated ketone with indole was developed for the synthesis of 3-substituted indoles with moderate to good yields. A Lewis acid such as AlCl3 was shown to be a promising promoter for in situ isomerization of β,γ-unsaturated ketone to its corresponding α,β-unsaturated ketone, then undergoing Friedel–Crafts Michael addition reaction with indole to afford 3-substituted indole.
關鍵字 Friedel–Crafts reaction Michael reaction;3-Substituted indole;β,γ-Unsaturated ketone;α,β-Unsaturated ketone
語言 en_US
ISSN 1568-5675
期刊性質 國外
收錄於 SCI
產學合作
通訊作者 Adam Shih-Yuan Lee
審稿制度 是
國別 USA
公開徵稿
出版型式 ,電子版,紙本
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