Multi-laminated metal hydroxide nanocontainers for oral-specific delivery for bioavailability improvement and treatment of inflammatory paw edema in mice
學年 104
學期 1
出版（發表）日期 2015-11-15
作品名稱 Multi-laminated metal hydroxide nanocontainers for oral-specific delivery for bioavailability improvement and treatment of inflammatory paw edema in mice
作品名稱（其他語言）
著者 Ranjith Kumar Kankala; Yaswanth Kuthati; Huei-Wun Sie; Hung-Yuan Shih; Sheng-I Lue; Shravankumar Kankala; Chien-Chung Jeng,Jin-Pei Deng; Ching-Feng Weng; Chen-Lun Liu; Chia-Hung Lee
單位
出版者
著錄名稱、卷期、頁數 Journal of Colloid and Interface Science 458, pp.217–228
摘要 Multiple layers of pH-sensitive enteric copolymers were coated over layered double hydroxide (LDH) nanoparticles for controllable drug release and improved solubility of hydrophobic drugs. The nano-sized LDH carriers significantly improved the accessibility of sulfasalazine molecules that have positively charged frameworks. In addition, the successful encapsulation of negatively charged enteric copolymers was achieved via electrostatic attractions. The multi-layered enteric polymer coating could potentially protect nanoparticle dissolution at gastric pH and accelerate the dissolution velocity, which would improve the drug bioavailability in the colon. Next, biological studies of this formulation indicated a highly protective effect from the scavenging of superoxide free radicals and diethyl maleate (DEM) induced lipid peroxidation, which are major cell signalling pathways for inflammation. The histological view of the liver and kidney sections revealed that the nanoformulation is safe and highly biocompatible. The animal studies conducted via paw inflammation induced by complete Freund’s adjuvant (CFA) revealed that enteric-coated LDH-sulfasalazine nanoparticles provided a sustained release that maintained the sulfasalazine concentrations in a therapeutic window. Therefore, this nanoformulation exhibited preferential efficacy in reducing the CFA-induced inflammation especially at day 4.
關鍵字 Layered double hydroxides;Nanoparticles;Oral drug delivery;Sulfasalazine;Eudragit copolymer;Inflammatory
語言 en_US
ISSN 1095-7103
期刊性質 國外
收錄於 SCI
產學合作
通訊作者 Chen-Lun Liu; Chia-Hung Lee
審稿制度 否
國別 USA
公開徵稿
出版型式 ,電子版,紙本
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機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/104669 )

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