Sex-specific factors for bone density in patients with schizophrenia
學年 103
學期 2
出版（發表）日期 2015-03-01
作品名稱 Sex-specific factors for bone density in patients with schizophrenia
作品名稱（其他語言）
著者 Chieh-Hsin Lin; Chun-Yuan Lin; Tiao-Lai Huang; Hong-Song Wang; Yue-Cune Chang; Hsien-Yuan Lane
單位 淡江大學數學學系
出版者 London: Lippincott Williams & Wilkins, Ltd.
著錄名稱、卷期、頁數 International Clinical Psychopharmacology 30(2), p.96–102
摘要 Patients with schizophrenia are susceptible to low bone mineral density (BMD). Many risk factors have been suggested. However, it remains uncertain whether the risk factors differ between men and women. In addition, the study of bone density in men is neglected more often than that in women. This study aims to examine specific risk factors of low BMD in different sexes. Men (n=80) and women (n=115) with schizophrenia, similar in demographic and clinical characteristics, were enrolled in three centers. Clinical and laboratory variables (including blood levels of prolactin, sex and thyroid hormones, cortisol, calcium, and alkaline phosphatase) were collected. BMD was measured using a dual-energy X-ray absorptiometer. Men had lower BMD than women. Predictors for BMD in men included hyperprolactinemia (B=−0.821, P=0.009), body weight (B=0.024, P=0.046), and Global Assessment of Functioning score (B=0.027, P=0.043); in women, BMD was associated with menopause (B=−1.070, P<0.001), body weight (B=0.027, P=0.003), and positive symptoms (B=0.094, P<0.001). In terms of the effect of psychotic symptoms, positive symptoms were related positively to BMD in women, but not in men. The findings suggest that sex-specific risk factors should be considered for an individualized intervention of bone loss in patients with schizophrenia. Physicians should pay particular attention to bone density in men with hyperprolactinemia and postmenopausal women. Further prospective studies in other populations are warranted to confirm these findings.
關鍵字
語言 en_US
ISSN 0268-1315
期刊性質 國外
收錄於 SCI
產學合作
通訊作者 Lane, Hsien-Yuan
審稿制度 否
國別 GBR
公開徵稿
出版型式 電子版
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