Dynamic Structural Transformation of Resveratrol-Modified Stearate Liposomes Led to a Spontaneous Drug Release System
學年 103
學期 1
出版（發表）日期 2014-09-01
作品名稱 Dynamic Structural Transformation of Resveratrol-Modified Stearate Liposomes Led to a Spontaneous Drug Release System
作品名稱（其他語言）
著者 Chen, Li-Chou; Lin, Shih-Shan; Li, Cun-Zhao; Hsu, Hsiu-Fu; Weng, Yu-Jong; Cheng, Chien-Chung
單位 淡江大學化學學系
出版者 Oxford: Wiley-Blackwell Publishing Ltd.
著錄名稱、卷期、頁數 Journal of the Chinese Chemical Society 60(9), pp.1099-1102
摘要 A mono-substituted resveratrol derivative, resveratrol-modified stearate (RMS), was synthesized by selectively coupling of stearic acid to the monohroxyphenyl of resveratrol in order to enhance both the stability and bioavailability of resveratrol. The RMS self-assembles into liposomes and a series of suprastructural transformations into metastable helical ribbon, linear wire-like structures, and inert spherical nanoparticles were detected that may be induced by the hydrogen-bonding interactions. As a model for drug-release investigations, gold nanoparticles (AuNPs) were encapsulated successfully by RMS to generate vesicles and succeed to release AuNPs druing the transformation to a ribbon-like metastable stucture at ambient temperature.
關鍵字 Liposome; Resveratrol; Stearate; Helical transformation; Drug-release
語言 en_US
ISSN 2192-6549
期刊性質
收錄於 SCI
產學合作
通訊作者
審稿制度 是
國別 GBR
公開徵稿
出版型式 電子版
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