Long-term hepatic consequences of chemotherapy-related HBV reactivation in lymphoma patients
學年 94
學期 1
出版（發表）日期 2005-09-01
作品名稱 Long-term hepatic consequences of chemotherapy-related HBV reactivation in lymphoma patients
作品名稱（其他語言）
著者 Su, W.P.; Wen, C.C.; Hsiung, C.A.; Su, I.J.; Cheng, A.L.; Chang, M.C.; Tsao, C.J.; Kao, W.Y.; Uen, W.C.; Hsu, C.; Hsu, C.H.; Lu, Y.S.; Tien, H.F; Chao, T.Y.; Chen L.T.; Jacqueline Whang-Peng; Chen, P.J.
單位 淡江大學數學學系暨研究所
出版者 Beijing: Beijing Baishideng BioMed Scientific Co., Ltd
著錄名稱、卷期、頁數 World Journal of Gastroenterology 11(34), pp.5283-5288
摘要 AIM: To investigate the long-term consequences of chemotherapy-related HBV reactivation in patients with lymphoma. METHODS: This study was based on the database of published prospective study evaluating HBV reactivation in HBV lymphoma patients during chemotherapy. Deteriorated liver reserve (DLR) was defined as development of either one of the following conditions during follow-up: (1) newly onset parenchyma liver disease, splenomegaly or ascites without evidence of lymphoma involvement; (2) decrease of the ratio (albumin/globulin ratio) to less than 0.8 or increase of the ratio of INR of prothrombin time to larger than 1.2 without evidence of malnutrition or infection. Liver cirrhosis was diagnosed by imaging studies. RESULTS: A total of 49 patients were included. The median follow-up was 6.2 years (range, 3.9-8.1 years). There were 31 patients with and 18 patients without HBV reactivation. Although there was no difference of overall survival (OS) and chemotherapy response rate between the two groups, DLR developed more frequently in patients with HBV reactivation (48.4% vs 16.7%; P = 0.0342). Among the HBV reactivators, HBV genotype C was associated with a higher risk of developing DLR (P = 0.0768) and liver cirrhosis (P = 0.003). Four of five patients with sustained high titer of HBV DNA and two of three patients with multiple HBV reactivation developed DLR. Further, patients with a sustained high titer of HBV DNA had the shortest OS among the HBV reactivators (P = 0.0000). No patients in the non-HBV reactivation group developed hepatic failure or liver cirrhosis. CONCLUSION: Chemotherapy-related HBV reactivation is associated with the long-term effect of deterioration of hepatic function.
關鍵字 HBV reactivation;Liver function;Non-Hodgkin’s lymphoma;Chemotherapy
語言 en_US
ISSN 1007-9327
期刊性質 國外
收錄於
產學合作
通訊作者
審稿制度 否
國別 USA
公開徵稿
出版型式 ,紙本
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