Fin reduction is a novel and unexpected teratogenic effect of amikacin-treated zebrafish embryos
學年 100
學期 2
出版（發表）日期 2012-02-01
作品名稱 Fin reduction is a novel and unexpected teratogenic effect of amikacin-treated zebrafish embryos
作品名稱（其他語言）
著者 Chen, Y.H.; Tsai, I.T.; Wen, C.C.; Wang, Y.H.; Cheng, C.C.; Hu, S.C0; Chen, Y.H.
單位 淡江大學數學學系暨研究所
出版者 New York: Informa Healthcare
著錄名稱、卷期、頁數 Toxicology Mechanisms and Methods 22(2), p.151-158
摘要 We used zebrafish as a model to assess amikacin-induced embryotoxicity. We exposed zebrafish embryos to amikacin, using different amikacin doses (0-10 ppm), durations (12-48 h), and onsets (0, 24, 48 hpf). Amikacin-induced embryonic toxicity and reduced survival rate were found dependent on the exposure dose, duration and onset. Based on immunostaining with neuron-specific antibodies, amikacin reduced the number and size of zebrafish neuromasts. In addition, Amikacin caused pelvic, dorsal and anal fin defects in dose-dependent and duration-dependent manners. Proliferating cell nuclear antigen immunostaining revealed that amikacin-induced fin defects were not due to reduction of proliferating mesenchymal cells. TUNEL assay demonstrated that amikacin-induced fin defects might not associate with apoptosis. Therefore, further investigations are required to elucidate if other cell death pathways are involved in amikacin-induced fin defects.
關鍵字 Amikacin;fin;zebrafish;ototoxicity;neuromast
語言 en
ISSN 1537-6516
期刊性質 國外
收錄於 SCI
產學合作
通訊作者
審稿制度 否
國別 USA
公開徵稿
出版型式 ,電子版,紙本
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