Preparation of chitosan nanoparticles by spray drying and their antibacterial activity
學年 102
學期 2
出版（發表）日期 2014-04-01
作品名稱 Preparation of chitosan nanoparticles by spray drying and their antibacterial activity
作品名稱（其他語言）
著者 La Thi Kim Ngan; Wang, San Lang; Đinh Minh Hiep; Luong, Phung Minh; Vui, Nguyen Tan; Tran Minh Đinh; Dzung, Nguyen Anh
單位 淡江大學化學學系
出版者 Dordrecht: Springer Netherlands
著錄名稱、卷期、頁數 Research on Chemical Intermediates 40(6), pp.2165-2175
摘要 Chitosan nanoparticles were prepared from chitosan with different molecular weight by spray drying method. The morphology of chitosan nanoparticles were characterized by SEM and size distribution and zeta potential values were determined. Effect of chitosan solution concentrations, molecular weight of chitosan (MMW, HMW and VHMW) and size of spray dryer nozzles on average size, size distribution and zeta potential values of chitosan nanoparticles were investigated. Moreover, the effect chitosan nanoparticles and chitosan nanoparticles/amoxicillin complex on Staphylococcus aureus was also tested. The results showed that the average size of chitosan nanoparticles were in the range of 95.5 to 395 nm and zeta potential values of 39.3 to 45.7 mV depended on concentration and molecular weight of chitosan. The lower concentration and molecular weight of chitosan were used, the smaller size of chitosan nanoparticles and the higher zeta potential values were obtained. The testing for antibacterial activity against S. aureus indicated that chitosan nanoparticles strongly inhibited the growth of bacteria with the minimum inhibitory concentration (MIC) of 20µg/mL, which were lower than that of chitosan solution and amoxicillin. The antibacterial capacity of chitosan nanoparticles also depended on size, zeta potential values and molecular weight of chitosan. Complex of chitosan nanoparticles/amoxicillin could improve antibacterial activity of amoxicillin.
關鍵字 Chitosan nanoparticles;Antibacterial activity;Amoxicillin;Staphylococcus aureus
語言 en
ISSN 1568-5675;0922-6168
期刊性質 國外
收錄於 SCI
產學合作
通訊作者 Wang, San-Lang; Nguyen Anh Dzung
審稿制度 是
國別 NLD
公開徵稿
出版型式 ,電子版,紙本
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