Synergistic Effects of COMT and TPH2 on Social Cognition
學年 102
學期 1
出版（發表）日期 2013-08-01
作品名稱 Synergistic Effects of COMT and TPH2 on Social Cognition
作品名稱（其他語言）
著者 Lin, Chieh-Hsin; Huang, Kuo-Hao; Huang, Chieh-Liang; Chang; Chang, Yue-Cune; Tsai, Guochuan E.; Lane, Hsien-Yuan
單位 淡江大學數學學系
出版者 New York: Guilford Publications, Inc.
著錄名稱、卷期、頁數 Psychiatry: Interpersonal and Biological Processes 76(3), pp.273-294
摘要 Whether genetic factors affect social cognition, particularly emotion management, requires elucidation. This study investigates whether social cognition varies with genetic variations of COMT and tryptophan hydroxylase-2 (TPH2), which modulate dopamine and serotonin neurotransmissions respectively, and thereby emotion regulation. NIMH-recommended 'managing emotions branch and 2 subtasks' of MSCEIT and six neurocognition domains, and genotypes of COMT Val158Met and TPH2 G703T were measured in 150 Han-Chinese healthy adults. Subjects carrying the M allele (M group) of COMT exceeded Val/Val homozygotes (V group) in managing emotions branch ( p = 0.032) and emotional relation subtask ( p = 0.037). TPH2 T/T homozygotes (T group) excelled those with the G allele (G group) in emotional management subtask ( p = 0.025). Subjects with M+T variation surpassed the other 3 groups (M+G, V+T and V+G) in managing emotion branch ( p = 0.002), emotional relation subtask ( p = 0.023), and emotional management subtask ( p = 0.002). The findings remained after control for gender, age, education, and neurocognitive functions. Synergistically, the effect size of COMT-TPH2 combination surmounted the sum of separate effect sizes of COMT and TPH2. The findings suggest that genetic variations of COMT and TPH2 have synergistic effects on social cognition in the general population.
關鍵字
語言 en_US
ISSN 0033-2747
期刊性質 國外
收錄於 SCI
產學合作
通訊作者
審稿制度
國別 USA
公開徵稿
出版型式 紙本
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