The First Synthesis of 7-(Hydroxymethyl)thiepane-3,4,5-triols from D-(-)-Quinic Acid
學年 101
學期 2
出版（發表）日期 2013-02-18
作品名稱 The First Synthesis of 7-(Hydroxymethyl)thiepane-3,4,5-triols from D-(-)-Quinic Acid
作品名稱（其他語言）
著者 Shih, Tzenge-Lien; Gao, Wei-Lin
單位 淡江大學化學學系
出版者 Kidlington: Pergamon
著錄名稱、卷期、頁數 Tetrahedron 69(7), pp.1897-1903
摘要 Seven thiepanes, the seven-membered-ring thiosugars, were first synthesized in 11–12 steps starting from d-(−)-quinic acid. Each thiepane is unique for its flexible conformation with a hydroxymethyl group at its C7 position. The key step was the deprotection of ether groups in compounds 7, 8, and 18–21 by 1.0 M BCl3 of CH2Cl2 solution at −78 °C to lead to the corresponding thiepanes. These target molecules all exhibited the twisted chair conformation that fully agreed with our previous report.
關鍵字 Glycosidase inhibitors; d-(−)-Quinic acid; Thiepanes; Thiosugars
語言 en_US
ISSN 0040-4020
期刊性質 國外
收錄於 SCI
產學合作
通訊作者 Shih, Tzenge-Lien
審稿制度 是
國別 GBR
公開徵稿
出版型式 ,紙本
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