Diagnostic Performance of Initial Salivary Alpha-Amylase Activity for Acute Myocardial Infarction in Patients with Acute Chest Pain
學年 101
學期 1
出版（發表）日期 2012-10-01
作品名稱 Diagnostic Performance of Initial Salivary Alpha-Amylase Activity for Acute Myocardial Infarction in Patients with Acute Chest Pain
作品名稱（其他語言）
著者 Shen, Ying-Sheng; Chen, Wei-Lung; Chang, Hsin-Yu; Kuo, Hung-Yi; Chang, Yue-Cune ;Chu, Hsin
單位 淡江大學數學學系
出版者 New York: Elsevier
著錄名稱、卷期、頁數 The Journal of Emergency Medicine 43(4), pp.553-560
摘要 Background To rule out acute myocardial infarction (AMI) in chest pain patients constitutes a diagnostic challenge to emergency department (ED) physicians. Study Objectives To evaluate the diagnostic value of measuring salivary alpha-amylase (sAA) activity for detecting AMI in patients presenting to the ED with acute chest pain. Methods sAA activity was measured in a prospective cohort of 473 consecutive adult patients within 4 h of onset of chest pain. Comparisons were made between patients with a final diagnosis of AMI and those with non-AMI. Univariate analysis and multiple logistic regression model were used to identify independent clinical predictors of AMI. Results Initial sAA activity in the AMI group (n = 85; 266 ± 127.6 U/mL) was significantly higher than in the non-AMI group (n = 388; 130 ± 92.8 U/mL, p < 0.001). sAA activity levels were also significantly higher in patients with ST elevation AMI (n = 53) compared to in those with non-ST elevation AMI (n = 32) (300 ± 141.1 vs. 210 ± 74.1 U/mL, p < 0.001). The area under the receiver operating characteristic curve of sAA activity for predicting AMI in patients with acute chest pain was 0.826 (95% confidence interval [CI] 0.782–0.869), with diagnostic odds ratio 10.87 (95% CI 6.16–19.18). With a best cutoff value of 197.7 U/mL, the sAA activity revealed moderate sensitivity and specificity as an independent predictor of AMI (78.8% and 74.5%). Conclusions High initial sAA activity is an independent predictor of AMI in patients presenting to the ED with chest pain.
關鍵字 salivary alpha-amylase; chest pain; acute myocardial infarction; emergency department
語言 en_US
ISSN 0736-4679
期刊性質 國外
收錄於
產學合作
通訊作者
審稿制度 是
國別 USA
公開徵稿 Y
出版型式 紙本
相關連結

機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/83463 )

機構典藏連結