Correlation in Retinal Nerve Fiber Layer Thickness between two OCT Units
學年 100
學期 1
出版（發表）日期 2011-11-01
作品名稱 Correlation in Retinal Nerve Fiber Layer Thickness between two OCT Units
作品名稱（其他語言）
著者 Chen, Hsin-yi; Chang, Yue-cune; Lane, Hsien-yuan
單位 淡江大學數學學系
出版者 Philadelphia: Lippincott Williams & Wilkins
著錄名稱、卷期、頁數 Optometry and Vision Science 88(11), p.1326-1332
摘要 Purpose. It is expected that spectral-domain optical coherence tomography (SD-OCT) will replace time-domain (TD)-OCT in the near future. In this study, we applied a robust set of statistical analyses to evaluate the correlation between retinal nerve fiber layer (RNFL) thickness measurements obtained by SD-OCT and those obtained by TD-OCT in a Chinese population with different stages of glaucoma. Methods. A total of 40 patients with primary open-angle glaucoma, 31 with primary angle-closure glaucoma (PACG), 31 with suspected glaucoma (GS), 25 with ocular hypertension (OH), and 52 normal subjects were enrolled in this prospective, cross-sectional study. Eyes of all participants were imaged by a single trained operator using the Stratus TD-OCT (fast RNFL scan mode) system and the Cirrus SD-OCT (optic disc cube mode) system during the same visit. The correlations between RNFL thickness measurements obtained from the two OCT instruments were assessed using Pearson correlation analysis and generalized estimating equation (GEE), mixed effect, linear regression models, after adjusting for the effect of individual variation. Results. There was good correlation in RNFL thickness parameters between the two OCT devices, particularly in average RNFL thickness (Pearson Correlation, 0.8798 vs. GEE mixed model, 0.9470). The proposed GEE mixed model method showed better correlation than the Pearson correlation analysis in each RNFL thickness parameter between the two OCT measurements. Conclusions. Although the RNFL thickness measurements obtained by the TD-OCT system correlated well with those obtained by the SD-OCT system, clinicians should be cautious when interpreting RNFL thickness data for any subject undergoing longitudinal follow-up with different OCTs.
關鍵字 correlation; Stratus OCT; Cirrus OCT; Taiwan Chinese population
語言 en_US
ISSN 1040-5488
期刊性質 國外
收錄於 SCI
產學合作
通訊作者
審稿制度 是
國別 USA
公開徵稿
出版型式 紙本
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