UV-induced fin damage in zebrafish as a system for evaluating the chemopreventive potential of broccoli and cauliflower extracts
學年 99
學期 1
出版（發表）日期 2011-01-01
作品名稱 UV-induced fin damage in zebrafish as a system for evaluating the chemopreventive potential of broccoli and cauliflower extracts
作品名稱（其他語言）
著者 Chen, Yau-hung; Wen, Chi-chung; Lin, Chun-yun; Chou, Chi-yuan; Yang, Zhi-shiang; Wang, Yun-hsin
單位 淡江大學生命科學研究所; 淡江大學數學學系
出版者 New York: Informa Healthcare
著錄名稱、卷期、頁數 Toxicology Mechanisms and Methods 21(1), pp.63-69
摘要 This study applied broccoli and cauliflower extracts (whole, floret, and stem) to zebrafish larvae in parallel to receive 100 mJ/cm2 of UVB six times, and recorded their fin malformation phenotypes. Chemopreventive effects of each group, including UVB, whole-, floret-, and stem-extracts of broccoli and cauliflower on fin development were evaluated using Kaplan-Meier analysis, log-rank test, and Cox proportional hazards regression. Results showed that (1) zebrafish fins in the UVB + whole broccoli extract group are 6.20~9.32-times more likely to return to normal fins than ones in the UVB only group, but fins in the UVB + whole cauliflower extract group are only 5.13~11.10-times more likely to recover, indicated that whole broccoli and cauliflower extract had similar chemopreventive ability on fin development; and (2) the broccoli stem has the highest antioxidant capacity among other groups. In conclusion, zebrafish can be used as a system for evaluating the efficacy of other UVB protective compounds.
關鍵字 Broccoli; cauliflower; fin; skin cancer; UVB; zebra fish
語言 en_US
ISSN 1537-6516
期刊性質 國外
收錄於 SCI
產學合作
通訊作者 Wang, Yun-hsin
審稿制度
國別 USA
公開徵稿
出版型式 紙本
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