RGS4 Polymorphisms Predict Clinical Manifestations and Responses to Risperidone Treatment in Patients With Schizophrenia
學年 96
學期 2
出版（發表）日期 2008-02-01
作品名稱 RGS4 Polymorphisms Predict Clinical Manifestations and Responses to Risperidone Treatment in Patients With Schizophrenia
作品名稱（其他語言）
著者 Lane, Hsien-Yuan; Liu, Yi-Ching; Huang, Chieh-Liang; Chang, Yue-Cune; Wu, Po-Lun; Huang, Chiung-Hsien; Tasi, Guochuan E.
單位 淡江大學數學學系
出版者 Philadelphia: Lippincott Williams & Wilkins
著錄名稱、卷期、頁數 Journal of Clinical Psychopharmacology 28(1), pp.64-68
摘要 Objective: Polymorphisms of the gene encoding the regulator of G-protein signaling subtype 4 (RGS4) are associated with schizophrenia. This study aims to investigate the association of 4 RGS4 polymorphisms (single nucleotide polymorphisms [SNPs] 1, 4, 7, and 18), implicated in previous studies, with baseline symptoms and treatment response to risperidone in patients with schizophrenia. Methods: One hundred twenty patients with acutely exacerbated schizophrenia who had never been treated by atypical antipsychotics were recruited. They received optimal treatment of risperidone for up to 42 days in the inpatient research unit. Patients' social functions were monitored by Nurses' Observation Scale for Inpatients Evaluation and clinical manifestations, by Positive and Negative Syndrome Scale. Results: At baseline status, the A/A genotype at SNP7 of RGS4 was associated with poorer social function when compared with the G/G genotype. After risperidone treatment, the A/A genotype at SNP1 was associated with greater improvement at social function, and the A/A genotype at SNP18 was associated with greater improvement at social function, Positive and Negative Syndrome Scale total score, and positive- and negative-symptom subscale. Conclusions: These findings suggest that RGS4 variances influence clinical manifestations of schizophrenia as well as the treatment response to risperidone, suggesting that RGS4 plays a role in the fundamental process of disease pathophysiology.
關鍵字
語言 en
ISSN 0271-0749; 1533-712X
期刊性質 國外
收錄於 SCI
產學合作
通訊作者 Tasi, Guochuan E.
審稿制度 是
國別 USA
公開徵稿
出版型式 紙本
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