Epstein–Barr virus infection and plasma transforming growth factor-β1 levels in head and neck cancers
學年 97
學期 1
出版（發表）日期 2008-10-01
作品名稱 Epstein–Barr virus infection and plasma transforming growth factor-β1 levels in head and neck cancers
作品名稱（其他語言）
著者 Chen, Hong-wen; Yang, Sheau-fang; 張玉坤; Cheng, Yue-cune; Wang, Tao-yeung; Chen, Yu-jen; Lai, Yuen-liang
單位 淡江大學數學學系
出版者
著錄名稱、卷期、頁數 Acta Oto-Laryngologica 18, pp.1145-1151
摘要 Conclusions. In addition to the correlation of transforming growth factor (TGF)-β1 levels to the radiation toxicity, both Epstein–Barr virus (EBV) infection and postoperative status play roles in the change in plasma TGF-β1 levels in patients with head and neck cancers. Objectives. To assess the parameters involved in the change in plasma TGF-β1 level during concurrent chemoradiotherapy (CCRT). Patients and methods. Blood samples (n=307) before, during, and after treatment were obtained from 39 patients with head and neck cancers treated with definitive or adjuvant CCRT. In situ hybridization (ISH) was used to identify EBV-encoded RNA (EBER) in tissues from the primary tumor or metastatic lymph nodes. Plasma TGF-β1 level, white blood cell (WBC), and platelet count were assayed immediately before the first fraction of radiotherapy (RT), once a week during RT, and at the end of the RT course. The grades of mucositis and dermatitis were recorded weekly during CCRT. Results. Pretreatment TGF-β1 level and radiation toxicity were found to be significantly correlated with the increase of the plasma TGF-β1 level during CCRT (p<0.05), but correlation of platelet count was only found in patients whose tumors were EBV-positive (p=0.0042), and WBC count in those treated with postoperative adjuvant CCRT (p=0.004).
關鍵字 EBW;transforming growth factor-β1(TGf-β1; head and neck cancer;CCRT
語言 en
ISSN
期刊性質 國內
收錄於
產學合作
通訊作者
審稿制度 否
國別 TWN
公開徵稿
出版型式 ,電子版
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