| The effect of ultra-nanocrystalline diamond films on the proliferation and differentiation of neural stem cells | |
|---|---|
| 學年 | 97 |
| 學期 | 2 |
| 出版（發表）日期 | 2009-07-01 |
| 作品名稱 | The effect of ultra-nanocrystalline diamond films on the proliferation and differentiation of neural stem cells |
| 作品名稱（其他語言） | |
| 著者 | Chen, Ying-Chieh; Lee, Don-Ching; Hsiao, Chao-Yang; Chung, Yu-Fen; Chen, Huang-Chin; Joseph P. Thomas; Pong, Way-Faung; Tai, Nyan-Hwa; Lin, I-Nan; Chiu, Ing-Ming |
| 單位 | 淡江大學物理學系 |
| 出版者 | Amsterdam: Elsevier BV |
| 著錄名稱、卷期、頁數 | Biomaterials 30(20), pp.3428-3435 |
| 摘要 | The interaction of ultra-nanocrystalline diamond (UNCD) with neural stem cells (NSCs) has been studied along with its surface modification in order to improve its function as a biomaterial. Hydrogen- and oxygen-terminated UNCD films were compared with standard grade polystyrene in terms of their impact on the growth, expansion and differentiation of NSCs. When NSCs were cultured on these substrates in low serum and without any differentiating factors, hydrogen-terminated UNCD films spontaneously induced cell proliferation and neuronal differentiation. Oxygen-terminated UNCD films were also shown to further improve neural differentiation, with a preference to differentiate into oligodendrocytes. Hence, controlling the surface properties of UNCD could manipulate the differentiation of NSCs for different biomedical applications. These observations raise the potential for the use of UNCD as a biomaterial for central nervous system transplantation and tissue engineering. |
| 關鍵字 | Neural stem cells;Neural differentiation;Ultra-nanocrystalline diamond;ECM |
| 語言 | en |
| ISSN | 0142-9612 |
| 期刊性質 | 國外 |
| 收錄於 | SCI EI |
| 產學合作 | |
| 通訊作者 | Tai, Nyan-Hwa; Chiu, Ing-Ming |
| 審稿制度 | 是 |
| 國別 | NLD |
| 公開徵稿 | |
| 出版型式 | 紙本 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/53089 ) |
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