Change of plasma transforming growth factor-β1 levels in nasopharyngeal carcinoma patients treated with concurrent chemo-radiotherapy
學年 94
學期 1
出版（發表）日期 2005-08-01
作品名稱 Change of plasma transforming growth factor-β1 levels in nasopharyngeal carcinoma patients treated with concurrent chemo-radiotherapy
作品名稱（其他語言）
著者 Chen, Hong-wen; 張玉坤; Chang, Yue-cune; Lai, Yuen-liang; Chen, Yu-jen; Huang, Ming-jer; Leu, Yi-shing; Fu, Ying-kai; Wang, Ling-wei; Hwang, Jeng-jong
單位 淡江大學數學學系
出版者 Oxford University Press
著錄名稱、卷期、頁數 Japanese Journal of Clinical Oncology 35(8), pp. 427-432
摘要 Objective: Our aim was to study the correlation between plasma transforming growth factor (TGF)-β1 level and radiation-induced mucositis and dermatitis in nasopharyngeal carcinoma (NPC) patients. Methods: Blood samples obtained from patients treated with concurrent chemo-radiotherapy (CCRT) were divided into two groups according to the pre-treatment plasma TGF-β1 level (≥7.5 ng/ml as group 1 and <7.5 ng/ml as group 2). Enzyme-linked immunosorbent assay (ELISA) was used for the measurement of the TGF-β1 level. Radiation toxicity was evaluated according to Radiation Treatment Oncology Group criteria. Data were analyzed by the generalized estimation equation method. Results: TGF-β1 levels of group 1 patients were decreased significantly (P = 0.002) at the end of the treatment. The rate of decrease was 0.12 ng/ml per fraction (P = 0.02). The average TGF-β1 level in patients who suffered acute radiation morbidity (grade ≥2) was significantly higher (P = 0.0057) than that of those who suffered less (grade <2). Conclusion: A lower pre-treatment plasma TGF-β1 level and the grade of radiation toxicity both appeared to contribute to the elevated plasma TGF-β1 after CCRT.
關鍵字 transforming growth factor-β1 (TGF-β1);nasopharyngeal carcinoma;concurrent chemo-radiotherapy
語言 en
ISSN 0368-2811
期刊性質 國內
收錄於
產學合作
通訊作者
審稿制度 否
國別 TWN
公開徵稿
出版型式 ,電子版
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