| A novel reusable nanomechanics based protein biosensor with electrical manipulation | |
|---|---|
| 學年 | 93 |
| 學期 | 1 |
| 出版（發表）日期 | 2005-01-01 |
| 作品名稱 | A novel reusable nanomechanics based protein biosensor with electrical manipulation |
| 作品名稱（其他語言） | |
| 著者 | 李世元; Lee, Adam Shih-yuan; Hwang, R.-Z.; Huang, L.-S.; Chang, H.-S.; Wu, C.-W.; Tien, H.-C.; Lin, S. |
| 單位 | 淡江大學化學學系 |
| 出版者 | Institute of Electrical and Electronics Engineers (IEEE) |
| 著錄名稱、卷期、頁數 | Micro Electro Mechanical Systems, 2005. MEMS 2005. 18th IEEE International Conference on, pp.798-801 |
| 摘要 | A novel reusable biosensor of label-free biomolecular recognition based on the nanomechanics transduction in a micro-fabricated cantilever has been developed. The nanomechanics-based immunoassay biosensor was proven to be repeatedly used with desorption of the pre-bound antigen-antibody by an in-situ alternative electrical field. This new approach of electric manipulation in separating the antigen out of the antibody in a buffer fluid environment was confirmed in nanomechanics-based immunoassay biosensor in which a conventional desorption is long used with high concentrated acid solution in a range of pH 2/spl sim/3. The potential benefit of the electrical means over a conventional pre-bound antigen-antibody desorption of strong acid solution is to maintain long-standing protein activity in multiple uses such that the micro biosensor is reliable and reproducible in every detection. The complete sensing history from a monolayer of biolinker, to antibody and antigen is also first demonstrated in nanomechanics-based immunoassay. |
| 關鍵字 | Proteins;Biosensors;Immune system;Silicon;Sea surface;Stress;Nanoscale devices;Gold;Nickel;Electrodes |
| 語言 | en_US |
| ISSN | 1084-6999 |
| 期刊性質 | 國外 |
| 收錄於 | |
| 產學合作 | |
| 通訊作者 | |
| 審稿制度 | 否 |
| 國別 | USA |
| 公開徵稿 | |
| 出版型式 | ,紙本 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/25267 ) |
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