期刊論文
| 學年 | 112 |
|---|---|
| 學期 | 2 |
| 出版（發表）日期 | 2024-04-01 |
| 作品名稱 | Synthesis of 2‐(pyridylvinyl)chromen‐4‐ones and their N‐oxide analogs for assessment of their biological activities as anticancer agents |
| 作品名稱（其他語言） | |
| 著者 | Yu Chun Ding; Yi‐Cheng Chu; Chuan‐Hsin Chang; Jia‐Hua Liang; Jih‐Jung Chen; Tzenge‐Lien Shih |
| 單位 | |
| 出版者 | |
| 著錄名稱、卷期、頁數 | Arch. Pharm. 357(4) |
| 摘要 | 2-Styrylchromones have been shown to possess a broad spectrum of biological activities. Replacing the carbon atom in 2-styrylchromones with a nitrogen atom in the benzene rings forms 2-(pyridylvinyl)chromen-4-ones (aza-2-styrylchromones). We have synthesized a series of novel 2-(pyridylvinyl)chromen-4-ones and their pyridine N-oxides to evaluate them as potential anticancer agents against human non-small-cell lung cancer cells (A549). Among the 18 synthesized molecules, compounds 18 and 8a exhibited comparable inhibitory effects to 5-fluorouracil and showed no toxicity against normal cells. |
| 關鍵字 | aza‐2‐styrylchromones;human non‐small‐cell lung cancer cells;pyridine N‐oxides. |
| 語言 | en |
| ISSN | 1521-4184; 0365-6233 |
| 期刊性質 | 國外 |
| 收錄於 | SCI |
| 產學合作 | |
| 通訊作者 | 施增廉 |
| 審稿制度 | 是 |
| 國別 | USA |
| 公開徵稿 | |
| 出版型式 | ,電子版 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/125467 ) |