期刊論文
| 學年 | 110 |
|---|---|
| 學期 | 2 |
| 出版（發表）日期 | 2022-07-06 |
| 作品名稱 | A universal strategy for the fabrication of single-photon and multiphoton NIR nanoparticles by loading organic dyes into water-soluble polymer nanosponges |
| 作品名稱（其他語言） | |
| 著者 | Yang, L.-X.; Liu, Y.-C.; Cho, C.-H.; Chen, Y.-R.; Yang, C.-S.; Lu, Y.-L.; Zhang, Z.; Tsai, Y.-T.; Chin, Y.-C.; Yu, J.; Pan, H.-M.; Jiang, W.-R.; Chia, Z.-C.; Huang, W.-S.; Chiu, Y.-L.; Sun, C.-K.; Huang, Y.-T.; Chen, L.-M.; Wong, K.-T.; Huang, H.-M.; Chen, C.-H.*; Chang, Y. J.*; Huang, C.-C.*; Liu, T.-M. * |
| 單位 | |
| 出版者 | |
| 著錄名稱、卷期、頁數 | Journal of Nanobiotechnology 20, 311 |
| 摘要 | The development of optical organic nanoparticles (NPs) is desirable and widely studied. However, most organic dyes are water-insoluble such that the derivatization and modification of these dyes are difficult. Herein, we demonstrated a simple platform for the fabrication of organic NPs designed with emissive properties by loading ten different organic dyes (molar masses of 479.1–1081.7 g/mol) into water-soluble polymer nanosponges composed of poly(styrene-alt-maleic acid) (PSMA). The result showed a substantial improvement over the loading of commercial dyes (3.7–50% loading) while preventing their spontaneous aggregation in aqueous solutions. This packaging strategy includes our newly synthesized organic dyes (> 85% loading) designed for OPVs (242), DSSCs (YI-1, YI-3, YI-8), and OLEDs (ADF-1–3, and DTDPTID) applications. These low-cytotoxicity organic NPs exhibited tunable fluorescence from visible to near-infrared (NIR) emission for cellular imaging and biological tracking in vivo. Moreover, PSMA NPs loaded with designed NIR-dyes were fabricated, and photodynamic therapy with these dye-loaded PSMA NPs for the photolysis of cancer cells was achieved when coupled with 808 nm laser excitation. Indeed, our work demonstrates a facile approach for increasing the biocompatibility and stability of organic dyes by loading them into water-soluble polymer-based carriers, providing a new perspective of organic optoelectronic materials in biomedical theranostic applications. |
| 關鍵字 | Polymer;Near-infrared red;Optoelectronic material;Photodynamic therapy;Theranostic;Multiphoton microscopy;Fluorescence imaging |
| 語言 | en |
| ISSN | 1477-3155 |
| 期刊性質 | 國外 |
| 收錄於 | SCI |
| 產學合作 | |
| 通訊作者 | |
| 審稿制度 | 是 |
| 國別 | GBR |
| 公開徵稿 | |
| 出版型式 | ,電子版,紙本 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/123403 ) |