期刊論文
| 學年 | 103 |
|---|---|
| 學期 | 1 |
| 出版（發表）日期 | 2014-11-28 |
| 作品名稱 | A sensitive bithiophene-based biosensor for interferon-gamma characterization and analysis |
| 作品名稱（其他語言） | |
| 著者 | P.I. Tsai; S.S. Lee; S.T. Chou; C.M. Jan; Y.T. Chang; A.S.Y. Lee; C.K. Lee |
| 單位 | |
| 出版者 | |
| 著錄名稱、卷期、頁數 | Thin Solid Films 571(3), p.473-477 |
| 摘要 | Real-time, label-free monitoring offers a wide range of applications to the biotech field. We developed an integrated bio-sensing platform which adapts a circular polarization interferometry configuration and a phase modulated ellipsometer to improve the performance of biomolecular measurements. An bithiophene-based conductive linker-5′-(mercapto)-[2, 2′-bithiophene]-5-carboxylic acid was developed for detecting antibody–antigen interactions. In this study, the biomarker interferon-gamma (IFN-γ), one of the most important indicators of tuberculosis, was chosen to test and verify the sensitivity of our measurement system. Our experimental results showed that an increase in the concentration of the IFN-γ (64 pM to 1 μM) was usually accompanied by a phase increase. This result is good evidence that our biosensing system can be useful for analyzing biomolecular interactions. |
| 關鍵字 | Surface plasmon resonance;Ellipsometry;Interferon-gamma;Phase-interrogation;Bithiophene |
| 語言 | en |
| ISSN | 1879-2731 |
| 期刊性質 | 國外 |
| 收錄於 | SCI |
| 產學合作 | |
| 通訊作者 | |
| 審稿制度 | 否 |
| 國別 | NLD |
| 公開徵稿 | |
| 出版型式 | ,電子版 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/120794 ) |