期刊論文
| 學年 | 105 |
|---|---|
| 學期 | 2 |
| 出版（發表）日期 | 2017-04-19 |
| 作品名稱 | Raman Spectrometric Detection Methods for Early and Non-Invasive Diagnosis of Alzheimer's Disease |
| 作品名稱（其他語言） | |
| 著者 | Chia-Chi Huang; Ciro Isidoro |
| 單位 | |
| 出版者 | |
| 著錄名稱、卷期、頁數 | Journal of Alzheimer's Disease 57(4), p.1145-1156 |
| 摘要 | The continuous increasing rate of patients suffering of Alzheimer’s disease (AD) worldwide requires the adoption of novel techniques for non-invasive early diagnosis and monitoring of the disease. Here we review the various Raman spectroscopic techniques, including Fourier Transform-Raman spectroscopy, surface-enhanced Raman scattering spectroscopy, coherent anti-Stokes Raman scattering spectroscopy, and confocal Raman microspectroscopy, that could be used for the diagnosis of AD. These techniques have shown the potential to detect AD biomarkers, such as the amyloid-β peptide and the tau protein, or the neurotransmitters involved in the disease (e.g., Glutamate and γ-Aminobutyric acid), or the typical structural alterations in specific brain areas. The possibility to detect the specific biomarkers in liquid biopsies and to obtain high resolution 3D microscope images of the affected area make the Raman spectroscopy a valuable ally in the early diagnosis and monitoring of AD. |
| 關鍵字 | Alzheimer's disease;amyloid-β peptide;brain tissue;diagnosis;Raman spectroscopy;tau protein |
| 語言 | en_US |
| ISSN | 1875-8908 |
| 期刊性質 | 國外 |
| 收錄於 | SCI |
| 產學合作 | |
| 通訊作者 | |
| 審稿制度 | 是 |
| 國別 | NLD |
| 公開徵稿 | |
| 出版型式 | ,電子版,紙本 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/120053 ) |