期刊論文
| 學年 | 101 |
|---|---|
| 學期 | 2 |
| 出版（發表）日期 | 2013-02-01 |
| 作品名稱 | Association Between Plasma Endothelin-1 and Severity of Different Types of Glaucoma |
| 作品名稱（其他語言） | |
| 著者 | Chen, Hsin-Yi; Chang, Yue-Cune; Chen, Wen-Chi; Lane, Hsien-Yuan |
| 單位 | 淡江大學數學學系 |
| 出版者 | Philadelphia: Lippincott Williams & Wilkins |
| 著錄名稱、卷期、頁數 | Journal of Glaucoma 22(2), pp.117-122 |
| 摘要 | Purpose: Endothelin-1 (ET-1) has been suggested to play an important role in the pathogenesis of glaucoma. Herein, we studied whether increased levels of plasma ET-1 are associated with changes in the visual field and changes in optical coherence tomography (OCT)-measured retinal nerve fiber layer (RNFL) thickness in patients with different types of glaucoma.
 
 Patients and Methods: Plasma concentration of ET-1 was determined in 31 patients with primary open-angle glaucoma, 18 patients with normal tension glaucoma, 16 patients with primary angle-closure glaucoma, and in 37 normal controls. In all participants, visual field testing was performed and OCT was used to measure RNFL thickness. The correlation between mean ET-1 level and changes in the visual field (mean deviation, dB) and changes in OCT-measured RNFL thickness in 1 randomly selected eye from each patient in each group was then evaluated.
 
 Results: The ET-1 level was 3.27±1.25 pg/mL in the primary open-angle glaucoma group (−14.09±8.76 dB), 3.12±1.46 pg/mL in the normal tension glaucoma group (−8.87±6.15 dB), 2.58±.22pg/mL in the primary angle-closure glaucoma group (−14.55±10.2 dB), and 1.53±1.49 pg/mL in the control group. Although mean ET-1 levels were significantly higher in all 3 of the glaucoma groups than in the control group, there was no significant difference in ET-1 level among the 3 glaucoma groups. In addition, no significant correlation was found between levels of plasma ET-1 and structural or functional changes in patients with different types of glaucoma.
 
 Conclusions: There was no correlation between plasma levels of ET-1 and severity of glaucoma. The role ET-1 plays in the pathogenesis of glaucoma remains to be determined. |
| 關鍵字 | |
| 語言 | en |
| ISSN | 1057-0829 |
| 期刊性質 | 國外 |
| 收錄於 | SCI |
| 產學合作 | |
| 通訊作者 | Chen, Hsin-Yi |
| 審稿制度 | 是 |
| 國別 | USA |
| 公開徵稿 | |
| 出版型式 | 紙本 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/93126 ) |