期刊論文
| 學年 | 94 |
|---|---|
| 學期 | 1 |
| 出版（發表）日期 | 2005-08-01 |
| 作品名稱 | Change of plasma transforming growth factor-β1 levels in nasopharyngeal carcinoma patients treated with concurrent chemo-radiotherapy |
| 作品名稱（其他語言） | |
| 著者 | Chen, Hong-wen; 張玉坤; Chang, Yue-cune; Lai, Yuen-liang; Chen, Yu-jen; Huang, Ming-jer; Leu, Yi-shing; Fu, Ying-kai; Wang, Ling-wei; Hwang, Jeng-jong |
| 單位 | 淡江大學數學學系 |
| 出版者 | Oxford University Press |
| 著錄名稱、卷期、頁數 | Japanese Journal of Clinical Oncology 35(8), pp. 427-432 |
| 摘要 | Objective: Our aim was to study the correlation between plasma transforming growth factor (TGF)-β1 level and radiation-induced mucositis and dermatitis in nasopharyngeal carcinoma (NPC) patients. Methods: Blood samples obtained from patients treated with concurrent chemo-radiotherapy (CCRT) were divided into two groups according to the pre-treatment plasma TGF-β1 level (≥7.5 ng/ml as group 1 and <7.5 ng/ml as group 2). Enzyme-linked immunosorbent assay (ELISA) was used for the measurement of the TGF-β1 level. Radiation toxicity was evaluated according to Radiation Treatment Oncology Group criteria. Data were analyzed by the generalized estimation equation method. Results: TGF-β1 levels of group 1 patients were decreased significantly (P = 0.002) at the end of the treatment. The rate of decrease was 0.12 ng/ml per fraction (P = 0.02). The average TGF-β1 level in patients who suffered acute radiation morbidity (grade ≥2) was significantly higher (P = 0.0057) than that of those who suffered less (grade <2). Conclusion: A lower pre-treatment plasma TGF-β1 level and the grade of radiation toxicity both appeared to contribute to the elevated plasma TGF-β1 after CCRT. |
| 關鍵字 | transforming growth factor-β1 (TGF-β1);nasopharyngeal carcinoma;concurrent chemo-radiotherapy |
| 語言 | en |
| ISSN | 0368-2811 |
| 期刊性質 | 國內 |
| 收錄於 | |
| 產學合作 | |
| 通訊作者 | |
| 審稿制度 | 否 |
| 國別 | TWN |
| 公開徵稿 | |
| 出版型式 | ,電子版 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/41264 ) |