期刊論文
| 學年 | 95 |
|---|---|
| 學期 | 2 |
| 出版（發表）日期 | 2007-05-25 |
| 作品名稱 | Expeditious Synthesis of Tri- and Tetrahydroxyazepanes from d-(−)-Quinic Acid as Potent Glycosidase Inhibitors |
| 作品名稱（其他語言） | |
| 著者 | Shih, Tzenge-lien; Yang, Ru-ying; Li, Shiou-ting; Chiang, Cheng-fan; Lin, Chun-hung |
| 單位 | 淡江大學化學學系 |
| 出版者 | Washington: American Chemical Society |
| 著錄名稱、卷期、頁數 | Journal of Organic Chemistry 72(11), pp.4258-4261 |
| 摘要 | Several new stereoisomers of 3,4,6-trihydroxyazepanes and 7-hydroxymethyl-3,4,5-trihydroxyazepanes as well as known 3,4,5-trihydroxyazepanes were synthesized as potent glycosidase inhibitors from D-(-)-quinic acid in an efficient manner. The key step employs dihydroxylation of protected chiral 1,4,5-cyclohex-2-enetriols under RuCl3/NaIO4/phosphate buffer (pH 7) condition, followed by reductive amino cyclization. We found the choice of an appropriate protecting group to C1-OH of chiral 1,4,5-cyclohex-2-enetriols would increase the yields of cyclization. The preliminary biological data indicate some of these azepanes possess potent inhibition against alpha-mannosidase and alpha-fucosidase. |
| 關鍵字 | |
| 語言 | en |
| ISSN | 1520-6904 |
| 期刊性質 | 國外 |
| 收錄於 | SCI |
| 產學合作 | |
| 通訊作者 | Shih, Tzenge-lien; Lin, Chun-hung |
| 審稿制度 | 否 |
| 國別 | USA |
| 公開徵稿 | |
| 出版型式 | ,電子版,紙本 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/24974 ) |